HI Chris,
I think that I recall your industry and I can suspect the reason for the potential release.
Can you confirm that the gas is lighter than air please?
As far as I can remember/check at this point in time many are heavier, it's only these that I could drum up as lighter:
hydrogen, acetylene, hydrogen cyanide, ammonia, methane, carbon monoxide, and ethylene
Now I think one of those leaking and cloud forming in the roof with the potential of flammability would be pretty low on your list! ;)
I would be cautious about a ducted system, because you are creating a system, and that will require additional assessment to provide proof that it complies. Also if the gas is evolved under pressure, then it will have strem energy that may not be captured by a hood.
If you use high level wall fans, I am guesing that in the event of a release one of the prcautions will be to open main doors in the area to allow as much ventilation, then you would need exhaust only, yes, these would possibly need to be correctly rated, but they would be sold as a single unit CE marked for the purpose, with installation instructions, so would not necessarily need further assessment.
It depends on I think whether you want legal minimum, or a bit more.
There are standards out there which would help with compliance think EAWR/BS7671 links...
I am cautious about discussing too much about your company on the open internet tbh.
With self contained wall fans the shutters can be passive, or active, if wall mounted I would not worry about icing, especially as they will be at roughly the highest points in the building, they will be kept warm by thermal convection, whis is why I said wall, not roof.
If you are going to extract, you are going to loose heat from the building, that cannot be avoided, but, hopefully it's not going to be a common occurance, with good shutters and maintenance, yes the fan will bea cold spot, if your building is well insulated but it won't be a massive area.
I would suspect you have compressed air on site, so a secondary shutter pneumatically driven internally would help to conserve energy.
You do need to consider the SIL pr PL of the system though really, as it is hopefully going to be very low demand (i.e. never) but if you need it, then it must work!