Posted By nicolas hello All Recent research indicates that psoriasis is likely to be a disorder of the immune system, causes activity by T cells.These T cells trigger the inflammation and excessive skin cell reproduction seen in people with psoriasis. The immune system of the psoriasis patient start sending false signals. The skin then believes that it has been under attack and needs to rapidly regenerate in order to heal faster. One of the messengers often used by T cells is the TNF (Tumor Necrosis Factor) which is one of the first cytokines (mechanism by which cells communicate with one another) that appear during an inflammatory response. Unfortunate is the fact that T Cells usually call more T cells to help them control the false attack, causing the snow ball effect, spreading the psoriasis to other parts of skin in body. The basic defect lies within the skin cells themselves. A delicate balance between two internal control compounds: cAMP (cyclic adenosine monophosphate) and cGMP (cyclic gaunosine monophosphate), which are second messengers that carry signals from the cell surface to proteins within the cell, and controls the rate at which cells divide. Increases in cyclic GMP are associated with increased cell proliferation. Conversely, increased levels of cyclic AMP are associated with enhanced cell maturation and decreased cell proliferation. The investigation of these second messengers (cAMP, cGMP) may help to provide a clearer understanding of the physiology and pathology of psoriasis disease state (both decreased cAMP and increased cGMP have been measured in the skin of individuals with psoriasis). ======= In precise experimental conditions of frequency and duration of exposure, the cAMP-dependent protein kinase ( an enzyme that modifies other proteins by chemically adding phosphate groups to them, regulating the majority of cellular pathways, especially those involved in the transmission of signals within the cell) of human lymphocytes (a type of white blood cell involved in the human body's immune system) has been inhibited by electromagnetic waves. ====Rebalancing the cyclic AMP & GMP is a prime electromagnetic-therapeutic goal.==== p.s. If anybody interested I will speak about the electromagnetic-therapy nicolas

Posted By nicolas Hi Bob It is not a sales pitch!-I don’t try to sale nothing. I am sure you never had P related diseases... you are really lucky. I would like to wish you good luck and a long and healthy life continually. After fifty years of hardship with Psoriasis, Dry-Skin and Psoriasis Arthritis I stumbled on some laboratory research information websites. I am not a physician or a medical professional, that’s why I needed months to understand the basic defect of P, PA and DS. I’d like to have professional or self experience opinions about P related diseases and alternative therapy - this much!! nicolas

Posted By Jeffrey Watt Nicolas Thanks for the post. I see a valid health issue here. Psoriasis was thought for years to be brought on by different factors some of them occupational like the substances you are using, others thought they were genetic and others stress. This piece of quoted research is showing an immune respone, a self destruct signal in the body, which would suggest that working with MWfluids "ain't causing your psoriasis mate." I think this is valid and of general interest to those in Occ health. Fell free to disagree/purge/strike/discuss. Jeff

Posted By Peter Taylor14 Whats the question/issue??? Or does nickolas just want to tell us he has an illness?

Posted By Patrick Guyomard Dave just to give a reply to whats this got to do with H&S? If you're interested look up North Somerset Council v Brian Farmiloe, a conflict between H&S legislation and the DDA - H&S prevailed http://www.oldsquarecham...ases/newcase.asp?case=30 Regards Pad

Posted By Glyn Atkinson Unfortunately , by not starting off with an opening explanation to why the many facts and quotes given should be read and and understood by those on here who may have connections with issues involving Occupational Health, Nicolas has immediately alienated himself from the casual reader. If, as he states he is not selling anything, but rather soliciting opinions about the therapy mentioned, he would be better asking for anyone with like skin disease histories to discuss their symptoms and any available medicines or relief. Make it into a two way discussion, not throw lots of blocks of facts at us, then we can appreciate what can be a very unsettling disease for some sufferers. Points about fair interviews and bias against appearance have been lost within a rush of long bulky paragraghs. Here's a question from me - if someone with this skin ailment came for an interview, could you see past the skin to give a fair appraisal of their quality of work, and future worth to your company?

Posted By Glyn Atkinson My second question- after going through the whole thread carefully again, and after Naomi's kind comments - is to ask Nicolas whether his agenda is to educate people, or to have a dig because of a job interview that may have gone wrong on the grounds of the ailment being obvious to the interviewer. As people have stated, there appears to be some vitriol within the bulky paragraphs, and the supposed message behind the thread is getting quite lost and hard to bother trying to take in. The Occupation Health - equality at interview issues are quite interesting, as are any discrimination points that have been raised.