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#1 Posted : 14 September 2006 14:30:00(UTC)
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Posted By Medusa
Afternoon all,
A few years ago I did a pre-employment medical, including a drug/alcohol test which came up as a false positive as I had taken some headache tablets containing codeine. I am now working in an environement where random testing is carried out on a regular basis and where the same thing has happened although not to me. I'm also aware that other random things such as poppy seeds, cough medicines etc can also trigger a false positive. Does anyone know if there is a definitive list of what can trigger false positive results and where I can find it? I'm thinking that at least if the operatives know what can cause such false positives than they will remember to mention it before the test(with the best will in the world it can be difficult to remember whether you had headache tablets 2 days ago) and therefore avoiding unnecessary complications.

Any ideas?
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#2 Posted : 14 September 2006 15:06:00(UTC)
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Posted By Kieran J Duignan
Medusa

In response to your (intelligent) question, here are a couple of ideas:

1. The listserve where you're most likely to get a 'content-based' reply to the question 'Does anyone know if there is a definitive list of what can trigger false positive results and where I can find it? is the Chemical Hazards Communications Society. www.chcs.com Generally a very helpful bunch to their members (subscription is not expensive)

2. However, I wonder whether you're asking the right question as it may well be that a more fruitful approach is to think in terms of the probability of a 'false positive', which anyone with reasonable statistical knowledge of the kind of testing you're doing can tell you about.
After all, it's on the basis of probability that the increasingly strict controls on drugs in sports are conducted: a second test is used in the instance of positive testing on the grounds that the probability of two 'false positives' have a measurably low probability.

Maybe it would be simplest after all to look up your statistics tables and/or search the World Wide Web for probability data?

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#3 Posted : 14 September 2006 15:14:00(UTC)
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Posted By Calum Clark
Try this website for a bit more advice on false positives

http://www.ultimatedetox...ing-false-positives.htm#

There are 100s of things that can produce false postives in the intial screening test. The second test usually uses a different procedure to determine wether the positive is true or false

I don't think the testers will take anything employees tell them on face falue as those expecting a positive are likey to tell lies. However, letting your staff know that false positives are possible but are cleared up by a secondary test might help allieviate any fears that they will be dsicplined for washing down their poppy seed roll with a glass of soluable solpadine.

Calum
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#4 Posted : 14 September 2006 15:27:00(UTC)
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Posted By Medusa
Thanks for the reply Kieran
I've had a google about to try to find this info but so far have just hit a brick wall. It's probably my own fault as I've just done a Tool Box Talk with the operatives and mentioned that seemingly harmless medications such as decongestants can trigger a false positive. And so the obvious question came back to me "What else can do this?".

Before I started work here there was a similar case of someone having taken a well known headache tablet containing codeine and completely forgot to tell the tester as it seemed so harmless. So when the test came back as positive, the worst was assumed. I understand the test was carried out by the client and a re-test was carried out and came back negative. However the total amount of time from the initial test to result, and then re-test and result took over 2 weeks causing much anxiety to the individual concerned. I guess I was just trying to let the lads know what could possibly do this in order to avoid a similar situation. I suppose the easiest option is just to remember everything that you've taken and inform the tester beforehand.

Thanks anyway
Orla
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#5 Posted : 14 September 2006 15:38:00(UTC)
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Posted By Medusa
Thanks Calum,
I agree with the more sensible approach. I have already said that just because you're taking cough medicine does not mean you will be branded a crack addict however the lads were just asking me for a list of possible substances which would give a positive result.

Thanks anyway for the link
Orla
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#6 Posted : 14 September 2006 15:40:00(UTC)
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Posted By Kieran J Duignan
Medusa

Sorry for the inaccurate URL. Maybe I'm at the pre-Alzheimer stage and should always check the quality of my recall.

This time I've checked that the URL for the CHCS website is www.chcs.org.uk

Although they 'major' on labelling chemical hazards, many of the CHCS members are chartered chemists, very bright and generous (without being a soft touch!).

Besides briefing staff about probabilities involved in testing for chemicals, etc., one of the other factors to bear in mind is the tendency of some people towards anxiety. Unless communications about testing are excellently handled, they may trigger anxieties that actually have nothing to do with drugs but can be a source of distress for the individuals affected and of bewilderment or worse for their managers and colleagues.

Let us know how this works out.
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#7 Posted : 14 September 2006 15:47:00(UTC)
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Posted By Jonathan Sandler CMIOSH
If working on either LUL or Network Rail you can go to any SHEQ person who will advise accordingly, failing that (no pun intended) you can always ge a list from the testing company.
Regards
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#8 Posted : 14 September 2006 15:58:00(UTC)
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Posted By Medusa
Kieran,
I think that may be where the confusion arises. On this site we have many different contractors with many different policies towards this. So, say if a person gets a positive result, one company may offer counselling and re-test wheras another may offer you your P45. Mind you, I probably made this ten time worse by mentioning false postitives in the first place. That'll teach me for trying to be helpful and informative!
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#9 Posted : 14 September 2006 16:22:00(UTC)
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Posted By Kieran J Duignan
Don't beat yourself up too much, Medusa.

Far better to inform employees accurately about implications, generally speaking. That way, you've taken action that you could justify on the grounds of respecting those prone to anxiety, in compliance with the Disability Discrimination Act (under which claims for damages can be v. high).

It may seem trivial but anxiety can explode into bizarrely disturbed behaviour. Although I spent quite some qualifying as a counsellor as well as a chartered occupational psychologist, somehow it took me a lot longer to realise that 'employees' could display the same anxiety symptoms at work as 'personal clients' I see in my own office.

It's even trickier in the sense that an anxiety-prone employee is not a counselling client unless he/she chooses to become one, but a OSH professional may be expected to recognise the significance of anxiety-driven behaviour.

The hard lesson I think is for an employer to realise how health and safety legislation can become the first stage of a battle about allegedly unfair discrimination where damages can escalate.

As you might expect, clashes of this kind tend to be settled out of court, as neither claimant nor defendant are often inclined to go through the whole sorry saga in slow motion before an employment tribunal or a county court.
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#10 Posted : 14 September 2006 16:26:00(UTC)
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Posted By Mike
On the workers consent form there should be a box headed "Medication taken and when" or similar. It is very important to complete this fully so that the test lab can report effectively. They will interpret any generic names and are experienced in deciding what is medication. I can't give you the complete list but they usually screen for the groups cocaine, methadone, propoxyphene, opiates, barbiturates, benzodiazepines, amphetamines, cannabis (+ alcohol if required). Labs are all accredited by one body, or should be, so their reporting procedures are very similar. They should report along the lines of:

positive
negative
positive, consistent with declared medication
positive, consistent with medication not declared
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#11 Posted : 14 September 2006 16:31:00(UTC)
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Posted By Robert K Lewis
Off track a little- The sport governing bodies seem to have overcome the problems by creating a strict liability. I am still a bit unsure about things though because my understanding was that the A &B samples were simply fractions of the original single sample. If so how does one get positive and negative results from the A and B testing respectively?

The whole issue of reliability is one which many laboratories do not really want to address. Can any analytical technique involving human involvement in some manner be so exact to claim better than 95% accuracy + or - 5%, I doubt it somehow. When one adds in the interfering substance possibility the window of accuracy must open even wider.

Bob
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#12 Posted : 14 September 2006 18:00:00(UTC)
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Posted By Mike
Bob

You are correct. There is first a single sample which is divided and A/B samples should be initialled/dated by the employee. It could sometimes happen that the A sample is just above the threshold and the B sample just below it. It could also happen that since the B sample is tested later there might be deterioration of the substance.

In many different ways accredited labs are forced to address reliability/interferences by their accreditation body (UKAS). They are also obliged to explain these matters to anyone with a reason to ask. If they don't you can complain to UKAS.

There is always some statistical uncertainty. What matters is that the lab knows what it is.
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#13 Posted : 14 September 2006 19:44:00(UTC)
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Posted By John Murgatroyd
1. Telling those to be tested what will give [possible] false results means that those using drugs [either prescribed or illegal] will immediately stock-up on buns with poppy seeds, medicines containing opiates [codein and various meds with low amounts of morphine in etc], not forgetting nutmeg.....which gives false positives for various drugs.

2. You can hardly expect an employee with a medical condition needing constant medication to [willingly] tell his employer, noting it on a "confidential" report is doing just that....nothing is confidential as far as employers are concerned (people who willingly, and frequently, break H&S laws, tax laws and criminal laws are unlikely to pay any attention to data protections laws). I would advise anyone taking a drug or alcohol test NOT to fill in anything giving ANY notification of any medical condition at all, which is what giving people a list of meds you take does......let them use gas chromatography to find out what it is....too expensive ?.............tough. Cheap tests give cheap results.
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#14 Posted : 14 September 2006 19:56:00(UTC)
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Posted By Kieran J Duignan
John

Your argument about abuse of the DP and H&S laws may well be valid in many situations but there are also circumstances in which it is safe for an employee, at any level, to share personal information in confidence provided he/she is prepared to act on his/her rights.

These circumstances include
A. disclosure in confidence to a nurse or doctor, who risks being disbarred from practice if he/she violates professional confidentiality: this ethical stance appears to be the most valid reason for the remarkably robust status of these professions in the UK and Ireland;
B. disclosure of details of a physical or psychological impairment regulated under the Disability Discrimination Act, under which there is in principle no upper limit and which the legal staff of the DRC have made clear how strongly they are prepared to challenge employer abuse (including abuse by H & S professionals who invalidly attempt indirect discrimination of disabled staff.

H & S is becoming an area in which well-informed trades union professionals and lawyers are often well ahead of the field and are more than willing to challenge abuse very robustly.
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#15 Posted : 15 September 2006 00:23:00(UTC)
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Posted By John Murgatroyd
Thank you very much for your information. Being in the union-type of work I didn't know that.
However, standard practice for a company medical requires the person being examined to sign the agreement to be examined and contains a "disclosure" statement....so, that's the end of the "medical confidentiality"

I repeat: people who willingly break employment, tax and criminal laws are unlikely to worry about the DPA. That means employers, in case there is any doubt.
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#16 Posted : 15 September 2006 06:23:00(UTC)
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Posted By Kieran J Duignan
Neat illustration of 'self-limiting beliefs'
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#17 Posted : 15 September 2006 10:18:00(UTC)
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Posted By Medusa
Many thanks to all who took the time to reply as I've learnt some stuff about this process which was surprising (nutmeg...?).

Just to reiterate, all I was trying to achieve was to inform my operatives of possible false positive triggers so that they could inform the OCC before the test. As for anyone who is taking prescription meds for whatever reason, I see no problem with that as long as it does not affect them unduly while performing safety critical tasks and is absolutely not something to discriminate against. If anyone approached me with this, or indeed with a drug or alcohol problem, I would treat it with my version of patient confidentiality while dealing with it in an appropriate and sympathetic manner. I just wanted my lads to be better informed about the process so as to avoid any possible anxiety/worry.

Thanks again to you all
Have a nice weekend
Orla
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#18 Posted : 15 September 2006 15:54:00(UTC)
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Posted By Adrian Watson
Dear All,

Whether a positive test result means much is determined by the prevalence of drug use and the accuracy of the drug test.

The prevalence is how many people are using the drug at any point of time. The accuracy of the test can be quantified by sensitivity and specificity. Sensitivity is the fraction of people using the drug you are testing for who will have a positive test; i.e. how good the test is at picking up true-positives. Specificity is the fraction of persons not using the drug you are testing for who will have a negative test; i.e. how good the test is at avoiding false-positives.

If 1 in 100 persons use drugs, and the test picks up 99/100 people who have taken the drug (0.99 sensitivity) and only gives 1 in 100 false positives (0.99 specificity) a person who test positive after the first test has only a 50% chance of having taken a drug! As a screening test is rarely this good, they normally carry out a second test using a more sensitive and more specific test.

Regards Adrian Watson
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#19 Posted : 15 September 2006 17:11:00(UTC)
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Posted By John Murgatroyd
It's not "self limiting beliefs". It's a recognition that if a system, any system, can be abused it will be.

Nutmeg:
http://www.drugscope.org...C11%5C1%5C1%5Cnutmeg.htm

Drug tests:
http://www.direct.gov.uk...T_ID=10026594&chk=mriwTy

When you are tested make sure that you LIMIT the amount of information that can be given to a third party. Better still, refuse to sign anything allowing transfer of information to anyone other than your GP.
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