Posted By FAH Hi again Andrew - how did the PPE issue go? This is a difficult question with a potentially wide range of essentially acceptable responses. There isn't really the correct place to go into a case-specific response, so the remainder of my comment is rather general. You can only reasonably be expected to produce CoSHH RAs for substances that are foreseeable and identifiable. Producing CoSHH RAs for mixtures is inherently more difficult - especially where the mixture may contain a range of substances, & quantities of those substances. With that in mind, I believe that your best option may be to develop a range of generic CoSHH [& associated] RAs for the principal groupings of substances/mixtures likely to be encountered that have the inbuilt proviso of being created to assist in recognising individual substances, & quantities, outside of the RA paramenters as they might be identified during the lab process. For the remainder, I would suggest adoption of a "research" standard CoSHH RA approach which suspects that certain characteristics may be present & proceeds on the basis that a higher level of protection will be applied until the evidence shows that a lower level may be appropriate. Hope this helps. Frank Hallett